【摘要】：目的:觀察口炎清顆粒治療慢性牙周炎的療效、安全性及對炎性細胞因子的影響。方法:110例慢性牙周炎患者隨機分為對照組(55例)和觀察組(55例)。對照組患者接受詳細的口腔衛生指導、全口齦上潔治、齦下刮治和根面平整等常規治療;觀察組患者在對照組治療的基礎上給予口炎清顆粒20 g,開水沖服,每日2次。兩組療程均為4周。觀察兩組患者的臨床療效,治療前后菌斑指數(PLI)、牙齦指數(GI)、牙周探診深度(PD)、臨床附著水平(CAL)、白細胞介素17(IL-17)和IL-21水平及不良反應發生情況。結果:兩組患者均完成治療,無失訪患者。觀察組患者總有效率顯著高于對照組,差異有統計學意義(P0.05)。治療后,兩組患者PLI、GI、PD、CAL、IL-17和IL-21水平均顯著低于同組治療前,且觀察組顯著低于對照組,差異均有統計學意義(P0.05)。兩組患者不良反應發生率比較,差異無統計學意義(P0.05)。結論:在常規治療的基礎上,口炎清顆粒治療慢性牙周炎的療效顯著,可顯著改善牙周癥狀,降低炎性細胞因子水平,且未增加不良反應的發生。
[Abstract]:Objective: to observe the efficacy and safety of Kouyanqing granule in the treatment of chronic periodontitis and its effect on inflammatory cytokines. Methods: 110 patients with chronic periodontitis were randomly divided into control group (55 cases) and observation group (55 cases). The patients in the control group received detailed oral hygiene guidance, subgingival cleaning, subgingival curettage and root leveling, while the patients in the observation group were given Kouyanqing granule 20 g, boiled water twice a day, on the basis of the treatment in the control group. The course of treatment in both groups was 4 weeks. To observe the clinical efficacy of the two groups, the plaque index (PLI), gum index (GI), periodontal probing depth (PD), clinical attachment level (CAL), IL-17 (IL-17) and IL-21 levels and the occurrence of adverse reactions before and after treatment. Results: both groups of patients completed the treatment, no lost follow-up patients. The total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P 0.05). After treatment, the levels of PLI,GI,PD,CAL,IL-17 and IL-21 in the two groups were significantly lower than those in the same group before treatment, and the levels in the observation group were significantly lower than those in the control group (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: on the basis of routine treatment, Kouyanqing granule is effective in the treatment of chronic periodontitis, which can significantly improve periodontal symptoms, reduce the level of inflammatory cytokines, and does not increase the occurrence of adverse reactions.
【作者單位】： 西南醫科大學口腔醫學院 西南醫科大學附屬口腔醫院
【分類號】：R276.8

【參考文獻】

相關期刊論文 前10條

1 張芳;陳燕;蔡哲;路東升;李婧;李宜磊;舒駿;郭麗麗;王曉霞;;補腎養陰清火法治療慢性牙周炎的臨床療效和對齦溝液中IL-1β、IL-6的影響[J];中華中醫藥雜志;2015年12期

2 王建琪;許麗華;;牙周炎患者外周血中Th亞群及齦溝液內IL-17的檢測[J];實用口腔醫學雜志;2015年06期

3 張靜;孟楣;王曉玉;葛平;江瑩;張賀;王芳;;新風膠囊對佐劑性關節炎模型大鼠的抗炎作用[J];中國藥房;2015年22期

4 姚小華;高菲;張國斌;李衛華;林青;王茜;;口炎清及其組分體外抑菌作用[J];中國微生態學雜志;2015年03期

5 龍寶軍;;口炎清顆粒聯合阿昔洛韋治療嬰幼兒皰疹性齦口炎的療效觀察[J];國際醫藥衛生導報;2014年14期

6 王琳瑛;;康復新液與口炎清治療復發性口腔潰瘍的療效對比[J];中國藥業;2014年08期

7 楊興Z，

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