【摘要】：目的探討左歸疏肝湯加減治療多囊卵巢綜合征(PCOS)不孕癥的臨床療效。方法選取2014年6月—2016年3月在浙江中醫(yī)藥大學(xué)附屬第二醫(yī)院婦科門診首次就診的PCOS患者150例,采用隨機數(shù)字表法分為對照組和試驗組各75例。對照組患者采用克羅米芬治療,試驗組患者在對照組的治療基礎(chǔ)上服用左歸疏肝湯加減治療,當直徑1.4 cm的卵泡數(shù)≥3個時停止治療,兩組的治療和觀察周期不超過6個月。比較兩組患者的血清內(nèi)分泌生殖激素水平、排卵和妊娠情況、臨床療效及不良反應(yīng)發(fā)生率。結(jié)果治療前兩組患者血清黃體生成素(LH)、卵泡刺激素(FSH)、睪酮(T)水平比較,差異無統(tǒng)計學(xué)意義(P0.05);治療后試驗組患者血清LH、FSH、T水平低于對照組,差異有統(tǒng)計學(xué)意義(P0.05)。治療后對照組患者血清LH、FSH水平低于治療前,試驗組患者血清LH、FSH、T水平低于治療前,差異有統(tǒng)計學(xué)意義(P0.05);而對照組患者血清T水平與治療前比較,差異無統(tǒng)計學(xué)意義(P0.05)。試驗組患者優(yōu)勢卵泡出現(xiàn)率、排卵率、臨床妊娠率高于對照組,差異有統(tǒng)計學(xué)意義(P0.05);兩組患者早期流產(chǎn)率比較,差異無統(tǒng)計學(xué)意義(P0.05)。試驗組患者臨床療效優(yōu)于對照組,差異有統(tǒng)計學(xué)意義(P0.05)。兩組患者子宮內(nèi)膜變薄、卵巢過度刺激綜合征發(fā)生率比較,差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論在服用克羅米芬的基礎(chǔ)上采用左歸疏肝湯加減治療,可以有效降低PCOS不孕癥患者的內(nèi)分泌生殖激素水平,提高優(yōu)勢卵泡出現(xiàn)率、排卵率及臨床妊娠率,療效確切。
[Abstract]:Objective to investigate the clinical effect of Zuogui Shugan decoction in the treatment of (PCOS) sterility in polycystic ovary syndrome (PCOS). Methods from June 2014 to March 2016, 150 patients with PCOS were enrolled in the gynecological clinic of the second affiliated Hospital of Zhejiang University of traditional Chinese Medicine. 75 patients in the control group and 75 patients in the experimental group were randomly divided into control group (n = 75) and experimental group (n = 75). The patients in the control group were treated with clomiphene, and the patients in the experimental group were treated with Zuogui Shugan decoction on the basis of the treatment in the control group. When the number of follicles in diameter of 1.4 cm was 鈮，

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