本文選題：神經(jīng)電信號(hào) + Cuff電極　； 參考：《第四軍醫(yī)大學(xué)》2008年碩士論文

【摘要】： Cuff電極是一種植入到外周神經(jīng)周圍的電極,可以用來(lái)記錄神經(jīng)電信號(hào),并可作為刺激電極用于神經(jīng)肌肉功能性刺激( functional neuromuscular stimulation,FNS)。本研究中我們首先建立了一種Cuff電極的構(gòu)建方法,并對(duì)其物理性能作了研究;然后將其作為一種神經(jīng)信號(hào)記錄電極,植入到狗的面神經(jīng)分支周圍,以探討我們所構(gòu)建的電極作為神經(jīng)電極的可行性;最后通過(guò)分析記錄到的信號(hào)的穩(wěn)定性以及對(duì)神經(jīng)的組織形態(tài)學(xué)的影響,研究應(yīng)用該電極進(jìn)行長(zhǎng)期植入時(shí)的穩(wěn)定性能。 目的: 1.構(gòu)建Cuff電極,并從物理性能方面研究其作為植入電極使用的可能性; 2.將構(gòu)建的Cuff電極,植入到狗的面神經(jīng)顴支周圍,提取神經(jīng)電信號(hào),以研究這種電極能否作為提取外周神經(jīng)電信號(hào)的電極使用; 3.將Cuff電極作為神經(jīng)記錄電極長(zhǎng)期植入動(dòng)物體內(nèi),從所提取到的神經(jīng)電信號(hào)的穩(wěn)定性,以及對(duì)植入電極組織形態(tài)的影響方面,觀察是否可以作為長(zhǎng)期植入電極使用? 方法: 1.使用預(yù)成套管縫合法構(gòu)建Cuff電極,然后從電極的導(dǎo)電性與絕緣性兩個(gè)方面測(cè)試其物理性能; 2.在狗面神經(jīng)顴支周圍植入Cuff電極,通過(guò)這個(gè)植入電極,提取神經(jīng)信號(hào)并進(jìn)行信號(hào)分析; 3.在狗面神經(jīng)顴支周圍植入Cuff電極,通過(guò)這個(gè)植入電極,分別在14天、6月后提取自然發(fā)生的神經(jīng)電信號(hào),比較分析不同時(shí)間提取的信號(hào)的差異性。通過(guò)組織形態(tài)學(xué)的方法,在Cuff電極植入后6個(gè)月觀察分析周圍有電極植入的神經(jīng)段落的組織形態(tài)學(xué)變化,以分析植入電極對(duì)神經(jīng)的影響。 結(jié)果: 1.應(yīng)用預(yù)成硅膠套管縫合法構(gòu)建出了Cuff電極,測(cè)試結(jié)果顯示其具有良好的導(dǎo)電性和絕緣性,可作為植入電極使用; 2.通過(guò)研究中所構(gòu)建的Cuff電極可以提取到能反映神經(jīng)所支配肌肉的功能作用狀態(tài)的神經(jīng)電信號(hào),說(shuō)明這種電極可以作為用來(lái)提取神經(jīng)電信號(hào)的神經(jīng)電極使用; 3.在電極植入后14天、6月均能提取出能反映眨眼動(dòng)作發(fā)生的神經(jīng)信號(hào),所提取到的自然睜眼狀態(tài)下的神經(jīng)信號(hào)在根方均值RMS和中位頻率MPF方面沒(méi)有明顯的變化。長(zhǎng)期植入Cuff電極的神經(jīng),未發(fā)現(xiàn)有明顯的損傷性形態(tài)改變,這說(shuō)明該電極可以作為長(zhǎng)期植入性電極進(jìn)行應(yīng)用。 結(jié)論: 本研究提供了一種神經(jīng)Cuff電極的制作方法,通過(guò)這種方法構(gòu)建的神經(jīng)Cuff電極,可以應(yīng)用于神經(jīng)電信號(hào)的研究和神經(jīng)功能修復(fù)等領(lǐng)域。
[Abstract]:The Cuff electrode is a kind of electrode implanted around the peripheral nerve. It can be used to record the nerve signal and be used as the stimulation electrode to stimulate the (functional neuromuscular stimulation. In this study, we first established a method of constructing Cuff electrode and studied its physical properties, then used it as a kind of nerve signal recording electrode and implanted it around the facial nerve branch of dog. The feasibility of using the electrode as nerve electrode was discussed. Finally, the stability of the electrode was studied by analyzing the stability of the recorded signal and the effect on the histomorphology of the nerve. Objective: 1. Cuff electrode was constructed, and the possibility of using it as implanted electrode was studied from the aspect of physical properties. 2. The constructed Cuff electrode was implanted around the zygomatic branch of the facial nerve of the dog and the nerve signal was extracted to study whether the electrode could be used as the electrode to extract the peripheral nerve signal. 3. The Cuff electrode was used as the nerve recording electrode for a long time to be implanted into the animal body. From the stability of the extracted nerve signal and the effect on the tissue morphology of the implanted electrode, can it be used as the long-term implanted electrode? Methods: 1. The Cuff electrode was constructed by preformed casing suture method, and the physical properties of the electrode were tested from two aspects: electrical conductivity and insulation. 2. The Cuff electrode was implanted around the zygomatic branch of the facial nerve of the dog. The nerve signal was extracted and analyzed by the implanted electrode. 3. The Cuff electrode was implanted around the zygomatic branch of the facial nerve of the dog. After 14 days and 6 months, the naturally occurring nerve signals were extracted, and the differences of the signals extracted at different times were compared and analyzed. Histomorphology was used to observe and analyze the histomorphologic changes of peripheral nerve segments implanted with Cuff electrodes 6 months after implantation, in order to analyze the effect of implanted electrodes on nerves. Results: 1. The Cuff electrode was constructed by using preformed silica gel casing suture method. The test results show that the electrode has good conductivity and insulation and can be used as implanted electrode. 2. The constructed Cuff electrode can extract the nerve signal which can reflect the function state of the nerve innervated muscle, which indicates that the electrode can be used as the nerve electrode to extract the nerve signal. 3. After 14 days of electrode implantation, the nerve signals which can reflect blink action were extracted in 6 months. The nerve signals extracted under natural open eyes showed no significant changes in root mean RMS and median frequency MPF. No obvious morphological changes were found in the nerve implanted with Cuff electrode for a long time, which indicated that the electrode could be used as a long-term implanted electrode. Conclusion: This study provides a method for the fabrication of neural Cuff electrodes. The neural Cuff electrodes constructed by this method can be used in the research of neural electrical signals and nerve functional repair and so on.
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2008
【分類號(hào)】：R312

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